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"Flow - through Hybridization" duration takes minutes not hours

Flow - through Hybridization" principle (US Patent 5,74,647) which is designed for the fastest, cleanest and the most affordable method to carry out any type of nucleic acid and protein array.

"Flow - through Hybridization" : The revolution brought about by molecular biology depended heavily on nucleic acid hybridization procedures. Hybridizations are used extensively in laboratories focusing on detecting specific nucleotide sequences in DNA, RNA, protein and many more other applications such as Single Nucleotide Polymorphism (SNP) based hybridization assays and the detections of genetic mutation are increasingly being applied in life-sciences.

The "Flow-through hybridization" concept is simple and easy, it provides optimal conditions for effective

The principle of the "Flow-through hybdridization" invention is based on directing the flow of the reacting molecules towards the target probes (immobilized on the membrane) in a pro-active manner, when the probes and targets are complementary to each others and they will subsequently form duplexes. The probes could be any molecules ranging from antibodies, antigens,receptors or nucleic acids. When comparing with conventional methods, this "Flow-through hybridization" technology increases the molecular binding rate by Thousand folds, thus allowing an efficient molecular annealing or hybridization to occurred. Flow-Through Hybridization platform also has an improvement on enhancing molecular interaction occus in three-dimensional volumes rather than the conentional two-dimensional surface.
Macro-array Flow-through Hybridization Format
Makes a cost-effective low-density macro-arry platform possible. Flow-through Hybridization technology is a perfect platform for a cost-effective low-density Macro-array, a potential replacement for the current expensive and complicated DNA Micro-array. Advantage Cost effective Reduced hybridization duration from hours down to minutes Require much less sample and reagent volumes Versatile and flexible platform for wide range of application High throughput Simple signal detection methodology