GENESIS®200, 2D & 3D Multiphoton Imaging System


World’s first suite of fully-automated, 3-D, quantitative, laser based imaging system for tissue imaging

  • Multi-photon microscope utilizing a high power laser
  • Customized optics
  • Fully automated
  • One-touch operation
  • Unstained tissues
  • Multi-organ capabilities


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Synopsis of the different features:


  • Eliminate staining artifacts while shortening sample preparation time

High Resolution  

  • Detect fine collagen fibers, up to 0.1µm, that are usually unnoticeable with traditional stains

Quantifiable Data

  • Provide fine measurements of disease progression and regression

3D Scanning

  • Realistic and 3D visualization of cellular and extracellular matrix architecture

 Reproducible Staging

  • Eliminate inter- and intra-observer discrepancy

 Multi-Organ Applications

  • Able to extend to multiple connective tissues (e.g. liver, kidney, brain, lung, breast, colon, prostate, skin, heart, etc) and oncology studies

Stain-Free Digital Pathology

  • Genesis®200 is the world’s first quantitative, fully-automated, stain-free, multi-organ, 2D & 3D multiphoton imaging system for tissue diagnostic.
  • The Genesis®200 is designed to assist in both preclinical and clinical research.
  • In the area of clinical studies, it provides pharmaceutical companies with specific morphological and extracellular matrix analysis as well as quantification for the accurate study of the progression of the disease.
  • Genesis®200 is able to detect any marginal improvement in treatment efficacy which is currently not available to pathologists with existing stain-based imaging techniques.
  • Enhancing current liver fibrosis staging with ultra-high resolution imaging and is capable of quantifying endogenous biomarkers within the tissue
  • This state-of-the-art technology enhances current liver fibrosis staging with ultra-high resolution imaging and is capable of detecting fine collagen dynamics that are otherwise unobserved with conventional staining techniques. This unique advantage, combined with software algorithms that isolate and quantify morphometric features (examples include collagen string, collagen intersection and region-based collagen segmentation) enables the objective and accurate staging of liver fibrosis



  • FibroIndexis the world’s leading image analysis solution for stain-free quantitative tissue diagnosis. A revolutionary approach in aiding diagnosis by providing both functional and morphological analysis of the cellular and extracellular matrix within the tissue.
  • LiverCloud, together with the Global Reference Index Database (GRID) for Hepatology, is the latest breakthrough in the cloud-based clinical assessment of liver patients.



We also provide partnership opportunities and services like:

  • Tissue Imaging Services
  • Image Analysis Package
  • Cell & Collagen Quantification
  • 2D / 3D Visualization
  • Tissue Morphological Analysis
  • Data Management

System Specification

a) Stain-free tissue imaging

b) Fiber-based femtosecond laser

c) Multiphoton fluorescence imaging with Second Harmonic Generation (SHG)

d) Ability to differentiate collagen types

e) 3 linear and nonlinear optical channels (2 transmissions + 1 reflection)

f) 3D imaging and visualization capability – image up to 300µm thick slice

g) Fully automated scanning and user-friendly

h) Maximum field of view at 400µm x 400µm under 10x objective lens

i) Sample loading capability up to a maximum of 10 slides

j) Polarization analysis

k) Versatility in imaging of multiple organs